Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis
Summary: Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions.We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liver metastasis.In contrast, mature high-density neutrophils inhibit the formation of liver metastases.Tr